Treatment of Clostridium difficile colitis in hamsters with a lipopeptide antibiotic, LY146032.
نویسندگان
چکیده
LY146032, an acidic lipopeptide antibiotic which inhibits the biosynthesis of cell wall peptidoglycan, was found to be effective in delaying death in a hamster model of pseudomembranous colitis. A dose of 0.05 mg/day was effective. The equivalent protection with vancomycin required a dose 100-fold higher, i.e., 5 mg/day.
منابع مشابه
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 31 7 شماره
صفحات -
تاریخ انتشار 1987